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Experimental studies to elucidate the beneficial effects of GLP-1 RA have mainly implicated the induction of natriuresis and the inhibition of oxidative stress, inflammation, and fibrosis [39,40,41]

Moderate alcohol consumption, defined as up to one drink per day for women and up to two drinks per day for men, is generally considered acceptable for most patients, though individual tolerance and circumstances should be considered

doi: 10.1038/nature14177, PMID: [DOI] [PMC free article] [PubMed] [Google Scholar] 23

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The function of metformin in upregulating GLP-1R level and PKA phosphorylation in endothelial cells may contribute to the synergistic protective effect of this combination therapy, which provides new insights on the interaction between metformin and GLP-1 agents (Fig
