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The thoracic fluid index significantly decreased at Tmax of liraglutide, i.e

Given the heterogeneity among GLP-1RAs in terms of pharmacokinetic profiles, therapeutic efficacy, adverse event rates, and dosing regimens, each agent should be assessed individually

weight or CV risk), with patient preferences and characteristics [62]

Since its initial approval in 2010, Novos liraglutide franchise has been a consistent contributor to its earnings, with Saxenda and Victoza bringing in $1.08 billion and $860 million last year, respectively

Placebo-controlled cross-over trial in patients with T2DM and albuminuria that shows that liraglutide therapy reduces 24-h urinary albumin excretion by lowering blood pressure, rather than by improving HbA 1c levels and body weight

Subsequently, an oral formulation for once-daily administration (Rybelsus , Novo Nordisk) was developed in 2019 to treat type 2 diabetes.45 Oral semaglutide is combined with sodium N-(8-[2-hydroxybenzoyl] amino) caprylate (salcaprozate sodium;SNAC), an absorption enhancer that improves semaglutides absorption across the gastric mucosa by transcellular mechanisms.46 By 2021, semaglutide (Wegovy , Novo Nordisk) administered by subcutaneous injection was also approved by the US FDA as an obesity treatment (Table 1).47 The doses of semaglutide available for subcutaneous injection are 0.25 mg, 0.5 mg, 1 mg, or 2 mg for type 2 diabetes, and 0.25 mg, 0.5 mg, 1 mg, 1.7 mg, or 2.4 mg for obesity, respectively