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Although NAD + is utilized as a cofactor or substrate by numerous enzymes to regulate redox status and cellular energy metabolism [36], sirtuins (SIRTs), which are NAD + -dependent deacetylases, play essential roles in cellular biological processes to maintain metabolic homeostasis [35,37,38,39]

The optimal dosing, duration of treatment, patient selection criteria, and long-term efficacy and safety for this potential indication are unknown

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