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Another strategy for downregulating LRRK2 activity is the use of anti-sense oligonucleotides (ASOs) to decrease LRRK2 expression levels

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Glucagon-like peptide-1 (GLP-1) drugs help people lose weight by making them feel fuller with less food and by signaling the brain that the stomach contains food, reducing their appetite and cravings

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GLP-1 binds to receptors in your brain's feeding centers and triggers fullness signals that reduce calorie intake by 2030%