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In March 2025, the FDA ended enforcement discretion for compounded tirzepatide, stating that no drug shortage existed for brand-name products

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Cost-effectiveness studies and the incorporation of pharmacoeconomic outcomes (e.g., episodes of hospitalization or other acute care) into late-stage clinical trials can help to generate data needed to understand the balance of benefits and harms for a given intervention (Fillit et al., 2010)

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