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And we summarized the main signal pathway activated by insulin in pancreatic cancer cells in Figure 2

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Both therapies increase metabolic demand and require adequate hydration, electrolyte balance, and hepatic function monitoring

They make healthy habits easier to sustain but work best within a supervised plan that includes nutrition and activity

Digestive effects remain the most common issue

The American College of Rheumatologys 2025 annual conference (ACR Convergence 2025) added to this picture, with data suggesting that patients on GLP-1 drugs had fewer rheumatic disease flares and that those with osteoarthritis saw greater improvements in pain and function compared to those on SGLT2 inhibitors, another diabetes drug class [11]