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Some of the adverse effects include: * Vitamin B12 deficiency * Reduced calcium and iron absorption * Osteoporosisrelated fractures * Increased risk of Clostridioides difficile infection * Increase risk of communityacquired pneumonia, particularly in hospitalized or elderly patients * Acute interstitial nephritis * Affect the metabolism of drugs (e.g., clopidogrel, warfarin, diazepam) altering their efficacy

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These humble foods have been shown in studies to ease perimenopausal symptoms naturally and safely, without the risks that come with hormonal drugs

Novo is also testing a subcutaneous form of amycretin delivered through regular injections like Wegovy and Zepbound, though the early stage trial is ongoing and data is not expected to be released until around 2025

In midlife physiology, dose decisions should reflect hormonal status, metabolic baseline, and lean mass preservation strategy