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It also maintains the vascular tone by enhancing the levels of endothelial nitric oxide (NO)

[DOI] [PMC free article] [PubMed] [Google Scholar] 36.La Sala L., Mrakic-Sposta S., Tagliabue E., Prattichizzo F., Micheloni S., Sangalli E., Specchia C., Uccellatore A.C., Lupini S., Spinetti G., et al

Glucagon-like peptide-1 receptor agonists: new evidence of kidney and cardiovascular protection from the FLOW and SELECT trials

GLP-1 medications work partly by influencing the brain circuits involved in set point regulation, which is why they produce larger and more sustained weight loss than dietary approaches

Side effects of weight loss drugs Four of the more popular GLP-1 medications Ozempic and Mounjaro (approved for diabetes) and Wegovy and Zepbound (approved for weight loss, plus a few other conditions) have similar side effects

This is attributed in large part to its heightened hypothalamic activity and augmented half-life, which together suppress appetite for longer periods [5, 6, 7, 10]