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In February 2026, the FDA publicly announced its intent to take action targeting mass-marketed, non-FDA-approved compounded GLP1 products, emphasizing that promotional claims implying equivalence to FDAapproved drugs can trigger enforcement risk

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Studies are demonstrating a plethora of positive effects on cardiovascular health, renal disease and liver disease, which may be directly related to the mitigation of the diabetes or obesity-associated risks of these complications or possibly direct protective effects

There have been concerns that GLP-1RAs may increase the risk of intestinal obstruction