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In the SURPASS-2 study, tirzepatide 15 mg resulted in a faster and greater decline in body weight ( 5.5 kg) compared to semaglutide 1.0 mg, more than doubling the proportion of patients achieving at least 10% weight loss (57% vs 24%) [3]
However, they significantly change health markers like blood sugar and cholesterol, which will be visible on medical blood work

Interestingly, a subgroup interaction suggested that non-diabetic and obese patients may derive greater MI benefit than their diabetic or non-obese counterparts

10.1016/j.neuropharm.2017.12.007 Neuropharmacology 72 ZhangH.ChuY.ZhengH.WangJ.SongB.SunY
The social experience of moving from a higher weight to a lower weight often involves receiving more attention, more respect, and more opportunities
