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But human observational evidence is increasingly reassuring on major malformations when confounding is handled carefullyfor example, large datasets show no substantial increased risk of major congenital malformations with early exposure, and a European teratology cohort reported no increase in major birth defects vs diabetes/high-BMI comparators

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Boehringer Ingelheim and Gubra initiate Phase 1 trials for BI 3034701, a novel triple-agonist peptide drug candidate for obesity.

The GLP-1 market is projected to exceed 100B USD by 2030

They present a framework to guide research and development teams based on the five most important technical determinants of project success and pipeline quality: the right target, the right patient, the right tissue, the right safety and the right commercial potential

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