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Rational combinations with orthogonal metabolic agents can be explored, with careful endpoint alignment and safety monitoring

Good diabetes control is essential because high blood sugar levels can weaken the immune system and create a more favorable environment for bacterial growth, increasing the risk of UTIs

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For example, niches may be created by addressing specific unmet needs in certain patient types (e.g., patients who prefer not to inject, or who failed prior lines of GLP-1s), or by addressing specific access issues (e.g., developing a lower-cost option, securing broader payer coverage)

So let's get into metric number one, which I call weight trend velocity