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doi: 10.1161/01.CIR.39.1.38

In individuals with obesity and diabetes, the incretin effect is diminished, contributing to poor glucose tolerance
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In this placebo-controlled trial, subjects were over the age of 45 years, had a BMI of 27 or above, and established cardiovascular disease

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Wu J, Williams GR, Branford-White C, Li H, Li Y, Zhu LM
