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A significant concern is that the most common adverse effects of GLP-1 agonistsnausea, vomiting, diarrhea, and abdominal painoverlap substantially with Crohn's disease symptoms

The active ingredient in Ozempic and Wegovy, made by Novo Nordisk, mimics a natural gut hormone called GLP-1

Experimental models have shown that male and female animals differ in mitochondrial substrate utilization under stress conditions, though findings vary by context

& Yang, X

GLP1(736) regulates somatostatin secretion by modulating calcium channels and influencing changes in membrane potential

If symptoms resolve with discontinuation and recur with rechallenge, alternative diabetes or weight management therapies should be considered