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doi: 10.23736/S2724-6507.20.03219-8

Commonly reported side effects include: Nausea or queasiness Reduced appetite Digestive changes Dry mouth Metallic or altered taste sensations These effects vary by individual, dosage, and duration of treatment

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In summary, the relatively higher expression of GLP-1R on -cells allows GLP-1 to indirectly inhibit glucagon secretion by promoting somatostatin secretion

A key target is the ventromedial hypothalamus since loss of Klb expression in this brain region blocks the ability of FGF21 to reduce carbohydrate intake and sucrose preference [61]