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Cost per member per month (PMPM) increased exponentially from $4.34 in 2022 to $19.19 in Q1-Q3 2024

FDA is acknowledging that the drugs dont have the same risk seen with older weight-loss medicines

The weekly injection schedule meant patients could maintain steady hormone levels with simpler regimens, improving real-world adherence

Contraindications: - Personal or family history of medullary thyroid carcinoma (MTC) - Multiple Endocrine Neoplasia syndrome type 2 (MEN2) - Serious hypersensitivity to orforglipron Safety profile: Common adverse effects include nausea, diarrhea, constipation, vomiting, abdominal pain, and fatigue

Regulatory approvals for obesity-specific indications and the shifting perception of obesity as a chronic medical condition rather than a lifestyle issue are further improving market momentum

In neurons, cAMP and PKA signaling pathways regulate synaptic plasticity by regulating pathways related to N-Methyl-D-aspartic acid (NMDA) and aminomethylphosphonic acid receptor signaling such as calcium influx into intracellular membranes to change synaptic plasticity for long-term potentiation related to memory function [42-45]