incretin mimetics glp 1 agonists - an overview Introduction to Diabetes Type 1

301 , R1755R1764 (2011)

32 A meta-analysis of over 76 clinical trials that investigated the efficacy of 15 different types of GLP-1RAs revealed that all 15 of the drugs were highly effective at treating T2D

Gilbert, P

These findings are concordant with those of observational studies that have also observed a decreased risk of major adverse cardiovascular events when comparing the GLP-1 receptor agonist-SGLT-2 inhibitor combination with different types of comparators: sulfonylurea-GLP-1 receptor agonist combination (hazard ratio 0.67, 0.59 to 0.89),30 metformin-sulfonylurea combination (hazard ratio 0.53, 0.35 to 0.80),31 and other combination regimens (odds ratio 0.70, 0.50 to 0.98).19 As these studies compared the GLP-1 receptor agonist-SGLT2 inhibitor combination with other drug combinations, they were designed to answer different clinical questions.193031 By contrast, our study was specifically designed to determine whether the add-on of a GLP-1 receptor agonist or an SGLT-2 inhibitor versus either drug class alone results in additional benefits on cardiovascular and renal outcomes

In cases where hair loss significantly impacts quality of life or fails to improve after 6 months, referral to a dermatologist for specialist assessment may be warranted

We could expect from early treatment with oral semaglutide and other GLP-1 analogues a better control of cardiovascular risks as a result of its actions exerted before atherosclerosis develops, in addition to the benefits of superior glucose control and weight loss