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Phase 2 data also showed retatrutide reducing liver fat more than would be expected from weight loss alone

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Gli eventi gastrointestinali sono stati frequenti (79,6% vs 39,9% placebo), con nausea al 55% vs 12,6% del placebo

At higher doses , meal planning becomes more important because the margin for error shrinks

But there are risks to any medication

For patients requiring surgical procedures, recent 2024 multi-society guidance (including the American Society of Anesthesiologists) indicates that most patients can continue GLP-1 receptor agonists perioperatively