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The initial muscle loss seen with GLP-1 RA treatment as well as the ongoing replacement of muscle with fat with treatment cycles involving treatment interruptions can result in unfavorable changes in body composition in patients with obesity that can have profoundly negative repercussions, and can exacerbate obesity-related metabolic and health concerns 14,15,16

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Sedentary patients who are not performing resistance training lose both the osteogenic stimulus that weight-bearing exercise provides and the muscle mass that protects joints

But millions are now taking these drugs far beyond those boundaries

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BMJ 344, d7771 (2012)