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Tirzepatide activates two pathways GLP-1 and GIP and in clinical trials produced greater average weight loss, particularly for patients at higher BMIs or with significant insulin resistance

These medications carry a boxed warning regarding thyroid C-cell tumor risk observed in rodent studies and are contraindicated in patients with a personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN2)

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Thats one of the reasons these were originally approved back in 2005 under the name Byetta to treat type 2 diabetes, the form of diabetes most attributed to obesity

Suspected side effects should be reported to the MHRA via the Yellow Card scheme at yellowcard.mhra.gov.uk or through the Yellow Card app