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Additionally, obesity-driven changes in the extracellular matrix particularly the deposition of fibronectin and collagen I provide a scaffold for tumour adhesion and invasion, reinforcing a tumour-promoting microenvironment [204]

The following checklist operationalizes the Stabilize Calibrate Accelerate Preserve framework introduced earlier in this guide

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Any suspected adverse reactions can be reported through the MHRA Yellow Card scheme

Brod M, Alolga SL, Meneghini L

Treatment typically starts at 2.5 mg once weekly for 4 weeks, allowing patients to acclimate to the medication while minimizing potential side effects