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Secondly, our analysis on the OpenVigil platform focused solely on the correlation between the drug and adverse event (AE), disregarding drug-drug interactions when multiple medications are prescribed

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Direct estimates were derived from head-to-head trials, while indirect estimates were obtained through a common comparator across the included trials

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36 The attachment of long fatty acids relayed by a carboxylic linkage leaves the affinity and activity almost unaffected