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Broader Indication Development# Recommendation : Pemvidutide Reason : Expanding into alcohol use disorder (RECLAIM Phase 2 trial) alongside obesity and MASH, potentially addressing a broader range of metabolic and liver conditions

In follow-up from the STEP 1 trial on semaglutide, average weight loss on semaglutide was 17.3% at week 68

doi: 10.1038/379069a0 [DOI] [PubMed] [Google Scholar] 23.Coveleskie K, Kilpatrick LA, Gupta A, et al

While some previous studies reported I values or mentioned heterogeneity, they lacked robust sensitivity testing across all outcomes

Telemetric intracranial pressure catheters enabled long-term intracranial pressure monitoring

it can centrally inhibit bone formation by binding to leptin receptors in the hypothalamus or locally promote bone formation and inhibit bone resorption by binding to receptors expressed on the surface of osteoblasts [100]