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To confirm the requirement of GLP-2R action and unveil the potential compensatory role of GLP-1R action in the expansion of intestinal surface area, male Glp2r / mice and WT controls were housed at TN (27 C) or cold (6 C) for 5 weeks

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Instead, they suggest that future advances in peptide therapeutics may arise from embracing biological complexity, provided it is approached with appropriate pharmacologic tools and conceptual frameworks

doi: 10.1016/j-pharmthera.2017.06.012

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That said, the severity and pattern may differ