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In a recent trial, semaglutide led to a 20% reduction in major adverse cardiovascular events (MACE) in patients []

GLP-1s account for 23% of first line diabetes therapy in 2025 up from 3% in 2021 Since 2019, the American Diabetes Association (ADA) has revised its Standards of Care each year to expand the role of GLP-1 receptor agonists and SGLT2 inhibitors as first-line treatments for T2D2

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Of these, Mounjaro had the fastest-growth rate over the year of 82.6%, then Ozempic with 31.7% sales growth and Jardiance at 28.9%