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Unfortunately, the occurrence of some adverse events has caused deep concern about the long-term safety of GLP-1RAs

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This warrants the need for pharmacologic interventions in a number of patients

They lower cortisol (your stress hormone), support insulin sensitivity, and reduce low-grade inflammation which means: Fewer crashes and cravings Less belly fat storage Better sleep and recovery For women in their 40s and 50s on the Josie program, this shift often brings more energy and better sleep too

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Inadequate response Not everyone responds equally to tirzepatide