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Some users store unmixed vials in the freezer for very long-term storage

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Patients may experience tingling or pins-and-needles that don't go away, burning sensations when nothing is hot, numbness in hands or feet, uncomfortable feelings when touched normally, or skin that feels wet or cold when it's not

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Unlike medications requiring therapeutic drug monitoring (such as immunosuppressants or certain antibiotics), tirzepatide dosing is standardized based on clinical response and tolerability rather than serum concentrations