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(Right) GLP-1 receptor agonist (GLP-1RA) reduces cholesterol accumulation by affecting the expression of genes in the hepato-enteral circulation and cholesterol reverse transport pathway, such as farnesoid X receptor (FXR), fibroblast growth factor-15 (FGF15), fibroblast growth factor receptor 4 (FGFR4), cytochrome P450 family 7 subfamily A member 1 (Cyp7a1), proprotein convertase subtilisin/kexin type 9 (PCSK9), low-density lipoprotein receptor (LDLR), etc

If retatrutide gains regulatory approval, wider availability could ensue across the world

Zhang Y, Xie JZ, Xu XY, et al

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As more data has become available, scientists have taken a closer look at how GLP-1 receptor agonists affect the brain

The multi-state implementation created particularly complex situations for members who lived in one state but worked in another, as the specific plan terms could vary by the employer location rather than the member residence