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The drugs have been shown to help people with obesity lose up to 15 percent of their body weight, but come with side effects that mean many struggle to stay on the drugs for longand weight regain is common for patients who come off the medication

[DOI] [PMC free article] [PubMed] [Google Scholar] 141.Holt M.K., Pomeranz L.E., Beier K.T., Reimann F., Gribble F.M., Rinaman L

In our review, we summarize evidence from randomized clinical trials and meta-analyses showing that ten approved and emerging obesity medications can improve a remarkably broad range of obesity-related conditions, including: Liver disease (MASLD and MASH) Chronic kidney disease PCOS (now increasingly referred to as PMOS, polyendocrine metabolic-ovarian syndrome) Obstructive sleep apnoea Osteoarthritis and physical functioning Cardiovascular disease Prediabetes and type 2 diabetes Importantly, many of these benefits are related to weight loss itself

Weeks 40 through 48 reach plateau where weight stabilizes

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