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But the clinical pattern is real: patients with MCAS, POTS, dysautonomia, multiple chemical sensitivity, and related conditions who exist in a state of chronic, low-level immune activation that conventional medicine struggles to categorize and largely fails to treat
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International precedent from other patent expiration events suggests that meaningful price reductions typically occur within 12-18 months of the first generic approval, particularly when multiple manufacturers compete simultaneously

doi: 10.1016/j.physbeh.2010.10.017

Orforglipron represents a true leap forward
