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Although lifestyle intervention, sodiumglucose cotransporter 2 (SGLT2) inhibitors, incretin-based therapies, and liver-directed treatments have broadened the therapeutic framework for this overlap phenotype, prospective evidence specifically addressing patients with coexisting MASLD and HFpEF remains limited

These harms outweigh any theoretical benefit because both drugs target the same biological pathways

"This drug represents a completely new type of treatment and has the potential to be of great importance for patients with type 2 diabetes and obesity," said paper author professor Shane Wright of the Karolinska Institutet in a statement

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