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Negative Mental Health Impact: Gastrointestinal Side Effects: Some people taking semaglutide may experience gastrointestinal side effects such as nausea, vomiting, diarrhea, or abdominal pain

It appears that only in RYGB and SG patients intestinal derived GLP-1 has a true endocrine role, while in healthy individuals, localized, paracrine and neuronal signals primarily define the GLP-1 physiology

The common hepatic branch of the vagus is not required to mediate the glycemic and food intake suppressive effects of glucagon-like-peptide-1

Some plaintiffs who have filed lawsuits allege that Eli Lilly should have warned them about Mounjaro and a possible association with vision loss caused by NAION
The shedding, while distressing, was not severe enough to outweigh the metabolic benefits of continued treatment
For now, the available data supports both approaches
