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GLP-1 therapies have also been shown to reduce the risk of long-term cardiovascular complications often experienced by people with T2D, such as heart attack and stroke

Certain individuals may experience fatigue due to underlying health issues or lifestyle factors unrelated to semaglutide GLP-1

Common gastrointestinal effects reported with GLP-1 therapy include: Nausea (commonly reported, especially during dose escalation) Constipation or diarrhoea Abdominal discomfort or bloating Reduced appetite and early satiety Regarding bowel movement colour specifically, changes in stool colour are not listed as adverse effects in UK SmPCs for GLP-1 receptor agonists

Broader settlements, if reached, would likely follow in 2027 or beyond

These are rare with GLP-1 medications but require emergency response if they occur

medRxiv [Preprint]