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Description
GIPR-deficient mice diet-induced obesity , GIPR antagonism AT-7687 GLP-1RA

Plasma concentrations of semaglutide were determined using a validated liquid chromatography-tandem mass spectrometry (LCMS/MS) method

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The fusion has been engineered to deliver sustained peptide activity in vivo in combination with reduced potency, to manage GLP-1 driven adverse effects at high dose, and a favourable manufacturability profile

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however, this contradicts established trial data favoring SGLT2 inhibitors for heart failure and should be interpreted cautiously due to possible residual confounding
