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In most studies, the adverse events did not lead to treatment discontinuation (12, 19, 21, 22, 2433)

doi: 10.2165/00003088-200746070-00003

[DOI] [PMC free article] [PubMed] [Google Scholar] 77.He Y, Huang Y, Xu H, Yang X, Liu N, Xu Y, et al

Cardiac structural and functional features in patients with type 2 diabetes mellitus and heart failure with preserved ejection fraction: a study based on propensity score matching

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these included 15 pharmacokinetic (PK) studies [13,14,15,16,17,18,19,20,21,22,23,24,25,26,27], one pharmacodynamic (PD) study [28], one review with detailed PK data not elsewhere published [29], three conference abstracts [30,31,32], one case report [33] and one case series [34] (Fig