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Marx N, Federici M, Schtt K et al (2023) 2023 ESC Guidelines for the management of cardiovascular disease in patients with diabetes

The weight effect runs through several parallel mechanisms: it activates satiety centers in the hypothalamus so patients feel full sooner and stay full longer, it slows gastric emptying, it modulates reward pathways so calorie-dense foods feel less compelling, and it stabilizes post-meal glucose and insulin

Summary: Evidence-Based Prevention Strategies Strategy 1: Conservative Dosing Philosophy TRIUMPH-4 shows clear dose-response relationship

Nakagawa A, Satake H, Nakabayashi H, Nishizawa M, Furuya K, Nakano S, et al

Clinical studies have indicated that tirzepatide can effectively reduce liver fat content in individuals with NAFLD

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