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Retatrutide does not yet have dedicated cardiovascular or renal outcome trials, though Phase 3 studies evaluating these endpoints are currently enrolling participants with expected completion in 2026

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Due to the increase in use, science may need time to catch up on the side effects as in, to determine both short-term and long-term side effects as the drugs are used for different conditions and for longer periods of time

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Patient Selection & Clinical Decision-Making When orforglipron reaches the market, clinicians will face a new decision matrix: which GLP-1 therapy, among a growing array of options, best fits each individual patient

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[DOI] [PubMed] [Google Scholar] 908.Goldenberg R.M., Berard L

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N Engl J Med 387(12):10891098 Rodriguez PJ, Goodwin Cartwright BM, Gratzl S, Brar R, Baker C, Gluckman TJ et al (2024) Semaglutide vs tirzepatide for weight loss in adults with overweight or obesity

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This osmotic laxative pulls water into the colon to keep things moving naturally without adding dangerous bulk

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