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Description
Retatrutide does not yet have dedicated cardiovascular or renal outcome trials, though Phase 3 studies evaluating these endpoints are currently enrolling participants with expected completion in 2026

Due to the increase in use, science may need time to catch up on the side effects as in, to determine both short-term and long-term side effects as the drugs are used for different conditions and for longer periods of time

Patient Selection & Clinical Decision-Making When orforglipron reaches the market, clinicians will face a new decision matrix: which GLP-1 therapy, among a growing array of options, best fits each individual patient

[DOI] [PubMed] [Google Scholar] 908.Goldenberg R.M., Berard L

N Engl J Med 387(12):10891098 Rodriguez PJ, Goodwin Cartwright BM, Gratzl S, Brar R, Baker C, Gluckman TJ et al (2024) Semaglutide vs tirzepatide for weight loss in adults with overweight or obesity

This osmotic laxative pulls water into the colon to keep things moving naturally without adding dangerous bulk
