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After 84 weeks, tirzepatide participants lost an average of 26.6%, while those on the highest dose of retatrutide lost around 24.2% over 48 weeks

Over time, certain serotonin autoreceptors (especially 5-HT1A autoreceptors) become desensitized

By the way, if the parents of 10 yr old Timmy, who live five counties over, decide to put him on ADHD medication, how is Timmy a member of "our children"

And as your dose increases, your appetite decreases further

As insulin sensitivity improves, the body becomes more efficient at using stored fat for energy rather than storing excess glucose as abdominal fat

Understanding the relationship between peptides and gut health provides useful context for why these GI adjustments are temporary rather than permanent