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Semaglutide 2.4mg (marketed as Wegovy) represented the previous benchmark for injectable weight loss medications

Interestingly, mice treated with bimagrumab alone displayed modestly elevated blood glucose levels (Figure 4A)

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In the semaglutide group, 569 out of 8803 patients (6.5%) experienced a primary cardiovascular end-point event, compared to 701 out of 8801 patients (8.0%) in the placebo group (hazard ratio, 0.80

313] and 2% per year in women [313]

Cardiovascular events: myocardial infarction, stroke, atrial fibrillation, and heart failure Metabolic parameters: LDL, HDL, triglycerides, HbA1c, BMI Disease progression: changes in liver enzymes, liver synthetic function, and the development of liver-related complications Composite outcomes were created using a combination of clinical diagnoses, lab abnormalities, and relevant medication use