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When muscle drops too much during weight loss, patients may experience: Reduced strength Lower energy Poorer exercise tolerance Increased frailty risk Greater chance of weight regain Less favorable body shape after weight loss Reduced metabolic flexibility Higher risk of functional decline with aging This is one reason the term skinny fat has become common in wellness conversations
20 The Trump Administration and the $245 Cap In a dramatic shift in late 2025, the Trump administration announced landmark agreements with Novo Nordisk and Eli Lilly to implement most-favored-nation (MFN) pricing for GLP-1 therapies in the U.S

More recently, GLP-1 receptor agonists have been trialled in people with obesity

Its focused GLP-1 profile makes it one of the most important reference points in modern metabolic peptide research

At the highest dose (equivalent to FDA-approved 17.2mg), participants who stayed on treatment for the full 72 weeks lost an average of 12.4% (~27 lbs)
