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7 In patients with T2DM, the release of incretin hormones is physiologically insufficient, thereby compromising the ability to adequately secrete insulin and also execute other physiologic processes required to meet the metabolic requirements to maintain normoglycemia

PMID: 39429457 | doi:10.2337/cd24-0062 Abdul-Rahman T et al
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References World Health Organization (WHO)

(2025) confirmed these patterns across the drug class: GLP-1 RAs significantly reduce lean mass (mean difference: 0.86 kg ), with the most potent agents for weight losssemaglutide 2.4 mg and tirzepatide 15 mgalso causing the greatest lean mass losses
