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Therefore, TRZ has a good therapeutic window with minimal toxicity (Min and Bain 2021)

Some people see meaningful improvement at higher semaglutide doses after plateauing at lower ones

Figure 6: Change in Body Weight (%) After 36-Week Open-Label Treatment Followed by Randomized Withdrawal (Study 4) in Patients with Obesity or Overweight Note: Displayed results are from the randomized population

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Scenario 3: repeated early dosing over multiple weeks This is the scenario that actually requires caution