how long have glp 1 drugs been around Chart: in 8 Americans Now Use GLP-1 for Weight Loss What are GLP-1s? | Mendinground
Description
Researchers have discovered that certain nutrients and plant compounds can boost the bodys own GLP1 production by tasting the nutrients in the gut and triggering hormone release

421,422 Remarkably, GLP-1R activation in certain nuclei (such as the VTA, NAc, and vHP) elicits reductions in food intake and body weight without concurrent nausea responses

Semaglutide 24 mg once weekly in patients with non-alcoholic steatohepatitis-related cirrhosis: a randomised, placebo-controlled phase 2 trial

The most common side effects of these medications are gastrointestinal (GI) issues like nausea, diarrhea, and abdominal pain

The first oral (pill) form of a GLP-1 (semaglutide, brand name Wegovy) became available in January 2026
doi: 10.1016/j.neuropharm.2014.04.007 100 CuiSSFengXBZhangBHXiaZYZhanLY