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95% CI, 1.412.75) in the CANVAS CVOT, which overall included 10,142 patients with T2DM and high cardiovascular risk [75]

The next wave dual and triple agonists (GLP-1 + GIP + glucagon: tirzepatide, retatrutide, survodutide) are showing superior fat loss, better hepatic outcomes, and potentially preserved lean mass

Primatesta P, Poulter NR

11 Amorim Moreira Alves, G., Teranishi, M., Teixeira de Castro Gonalves Ortega, A

The prolyl isomerase Pin1 regulates amyloid precursor protein processing and amyloid-beta production
