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Description
A 32-year-old woman with no prior thyroid history developed painless biphasic thyroiditis (initial hyperthyroidism followed by temporary hypothyroidism) after two months of tirzepatide therapy
They all activate GLP-1 receptors, and using two GLP-1 agonists simultaneously would increase side effect risk without proportional benefit
GLP-1RAs were initially developed as agents to control blood glucose in individuals with diabetes, but CVOTs over the last decade have established these medications as a cornerstone for the reduction of CV events in high-risk populations
In 2023, branded obesity drug sales reached $6 billion, and this figure is expected to grow exponentially as demand continues to rise and these medications are used to treat a broader range of diseases
One detail worth understanding is that phentermine tolerance develops unevenly across patients
These medications dont increase psychiatric risk and may actually improve certain psychiatric symptoms
