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About this article Cite this article Darbalaei, S., Chang, Rl., Zhou, Qt

Although the pathophysiological processes underlying the cardiovascular disease may improve with weight loss, weight loss alone is insufficient to fully account for the observed cardiovascular improvements

Loss of magel2, a candidate gene for features of Prader-Willi syndrome, impairs reproductive function in mice

The net effect would depend on which compartment is most affected in a given individual