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For researchers studying complex metabolic systems, this represents an entirely different experimental platform
Thats around 1 in 20 adults

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Sterne JAC, Hernn MA, Reeves BC et al (2016) ROBINS-I: a tool for assessing risk of bias in non-randomised studies of interventions

Cardiovasc Res 118(18):34343450 Dhore-Patil A, Thannoun T, Samson R, Le Jemtel TH (2021) Diabetes mellitus and heart failure with preserved ejection fraction: role of obesity