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Clarke and colleagues similarly noted that the majority of patients tolerated GLP-1RA therapy without requiring treatment cessation due to IBD-specific complications (96)

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In the TRIUMPH-4 trial , published by Eli Lilly in December 2025, participants taking the 12 mg dose lost an average of 28.7% of their body weight at 68 weeks , and WOMAC pain scores were reduced significantly

Fourth, real-world effectiveness data are limited, and observational studies are needed to evaluate generalisability, treatment persistence, and safety in routine practice while addressing confounding and time-varying therapy

Patients with active substance use may have compromised nutritional status, liver function, or medication adherence, potentially increasing risks