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Objective Investigate the association between GLP-1RAs use and intestinal obstruction in a large cohort of patients with type 2 diabetes mellitus (T2DM) in the U.S

In addition, it is likely that TCF7L2 functions as a modulator of vascular GLP-1 receptor expression.

The use of glucagon-like peptide-1 receptor agonists (GLP-1RAs), used to treat diabetes and obesity, may be associated with a wide range of health effects, both positive - such as a reduced risk of cardiometabolic disorders - and negative - an increased risk of gastrointestinal conditions or hypertension

Orforglipron does not require fasting or other dosing restrictions, which may offer a meaningful practical advantage for patients

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