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76 Clinical studies have shown that GLP-1 and its receptor agonist exenatide can improve human bronchial hyperresponsiveness (BHR) by inducing pulmonary vasorelaxation and phosphatidylcholine secretion through activation of the cAMP-PKA-dependent pathway, 77 and by stimulating the secretion of phosphatidylcholine (a major component of surfactant) through cAMP-dependent PKA and cAMP-dependent PKC, thereby improving lung function

Dietary triggers vary considerably between individuals but commonly include fatty foods, caffeine, alcohol, artificial sweeteners, and fermentable carbohydrates (FODMAPs)

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For a patient dealing with early nausea, persistent constipation, or symptoms that return after a treatment change, an individualized review may consider medical history, current medications, symptom severity, hydration, food intake, previous gastrointestinal concerns, and overall treatment goals